GSK has halted all shipments of ARIXTRA Starter Kits containing the Triad For important product information, log onto Arixtra mg/ ml solution for injection, pre-filled syringe. 2. .. Detailed information on this medicinal product is available on the website of the European . Arixtra is a medicine that helps prevent blood clots from forming in the blood This medicinal product contains less than 23 mg of sodium in each dose and.
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Used in conjunction with warfarin for treatment of DVT and acute PE when initial therapy is administered in the hospital. Anticoagulation results from rapid inhibition of factor Xa by antithrombin III bound to fondaparinux about fold greater informatin innate activity.
The activity of fondaparinux sodium is measured based on plasma drug concentrations quantified by anti-factor Xa activity using fondaparinux as the calibrator. Risk also increased by history of traumatic or repeated epidural or spinal puncture, spinal deformity, or spinal surgery. Importance of patients informing clinicians including dentists that they are receiving fondaparinux therapy before scheduling any invasive procedures.
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs. Several antithrombotic agents e. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Some packaging components e.
A synthetic pentasaccharide for the prevention of deep-vein thrombosis after total hip replacement. Bounameaux, H, Perneger T. Food and Drug Administration. Platelet function or global clotting function tests e. Importance of prescribimg patients who have had neuraxial anesthesia or spinal puncture to monitor for manifestations of spinal or epidural hematoma e.
If coadministration is essential, monitor patients closely 1 Arixtra fondaparinux sodium injection prescribing information. Efficacy and safety of fondaparinux versus enoxaparin informagion patients with acute coronary syndromes undergoing percutaneous coronary intervention: J Am Coll Cardiol. When selecting an appropriate thromboprophylaxis regimen, consider factors such as relative efficacy, bleeding risk, logistics, and compliance issues.
Discontinue platelet-aggregation inhibitors prior to initiation of fondaparinux 1 40 If prescriblng is essential, monitor patients closely 1 Periodic routine blood counts, including platelet counts, and tests for occult blood in stool recommended.
Discontinue platelet-aggregation inhibitors prior to initiation of fondaparinux 1 A randomized double-blind trial. Natural rubber-containing medical devices; user labeling.
Hull R, Pineo G. Used for extended prophylaxis i. Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism.
Monitor frequently for manifestations of neurologic impairment and treat urgently if neurologic compromise noted.
Arixtra Monograph for Professionals –
Avoid concomitant use of drugs that increase risk of bleeding unless essential for management of underlying condition e. Patients should be sitting or supine during administration. Binds selectively to antithrombin III; unable to inactivate thrombin. Optimal timing between administration of arixtrs and neuraxial procedures not known. Prezcribing Engl J Med. Initiate concurrent warfarin as soon as possible, 1 usually within 72 hours of fondaparinux injection; 1 20 ACCP recommends initiating warfarin simultaneously on the first day of fondaparinux treatment.
Consider potential benefits versus risks of spinal or epidural anesthesia or spinal puncture in patients receiving or being considered for thromboprophylaxis with anticoagulants. Am J Health-Syst Pharm. A new synthetic pentasaccharide for thrombosis prevention. Subscribe to receive email notifications whenever new articles are published.
Usual duration of therapy is 5—9 days, 1 3 4 5 6 although up to 11 days has been studied in clinical trials of orthopedic surgery.
Discontinue NSAIAs prior to initiation of fondaparinux 1 40 If coadministration is essential, monitor patients closely Anticoagulant effects may persist for 2—4 days following discontinuance of therapy in patients with normal renal function i.
If fondaparinux therapy is to be continued after hospital discharge, importance of instructing patient on proper administration of the drug, including injection technique. Fondaparinux compared with enoxaparin for the prevention of venous thromboembolism after elective major knee surgery.
Patients undergoing hip-fracture, hip- or knee-replacement surgery: Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.
Treatment and prevention of heparin-induced thrombocytopenia: Print this page Add to My Med List. Do not administer earlier than 6—8 hours after surgery because arixtrra increased risk of major bleeding.
Dosages for fondaparinux sodium and heparin, heparinoids, or LMWHs cannot be used interchangeably on a unit-for-unit or mg-for-mg basis 1 as they differ in the manufacturing process, anti-factor Prescribijg and antithrombin activity, and dosage.
Importance of informing patients of other important precautionary information.